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QStrain
is a user-friendly, interactive platform for screening genetic target sites
for high-risk infectious viruses and designing small interfering RNA (siRNA)/antisense ologinucleotide (ASO) treatments.
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It provides reference-guided multiple sequence alignment (MSA) of viral genomes including SARS-CoV-2,
Lassa, SFTSV, MERS-CoV, Influenza H1N1, Nipah, RSV, and Dengue virus which would be added gradually.
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The MSA result can be visualized in the form of frequency profile, homology (conservation) score, viral gene expression, and phylogenetic tree for a reference and user input sequences.
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Highly conserved regions will be used to predict target viral gene region and nucleic acid-based therapeutics including siRNA/ASO design.
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